Free light chains kappa can differentiate between myelitis and noninflammatory myelopathy
نویسندگان
چکیده
منابع مشابه
Clinical biomarkers differentiate myelitis from vascular and other causes of myelopathy
OBJECTIVE To assess the predictive value of the initial clinical and paraclinical features in the differentiation of inflammatory myelopathies from other causes of myelopathy in patients with initial diagnosis of transverse myelitis (TM). METHODS We analyzed the clinical presentation, spinal cord MRI, and CSF features in a cohort of 457 patients referred to a specialized myelopathy center wit...
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Dear Editor, Surfer’s myelopathy (SM) is a rare, acute spinal injury that is presumed to involve the major blood vessel supplying the thoracolumbar segment of the spinal cord. The injury typically follows prolonged hyperextension of the back. This condition was coined SM because it is seen most often in beginner surfers. Here we describe a case of a patient with SM that required differentiation...
متن کاملKappa Free Light Chains: Diagnostic and Prognostic Relevance in MS and CIS
BACKGROUND Quantification of kappa free light chains (KFLC) in cerebrospinal fluid shows high diagnostic sensitivity in multiple sclerosis and clinically isolated syndrome patients. However, a clearly defined threshold value is still missing and a possible prognostic value of the KFLC levels in these patients remains undefined. METHODS Results of KFLC quantification in 420 controls were used ...
متن کاملHigh sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis.
Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive - more than OCB testing - and specific for clinically isolated syndrome, relaps...
متن کاملCerebrospinal fluid free kappa light chains versus IgG findings in neurological disorders: qualitative and quantitative measurements.
In this study free kappa light chains in cerebrospinal fluid (CSF) were determined both by an affinity mediated capillary blotting technique after isoelectric focusing (IEF) in agarose gel and by a quantitative enzyme linked immunosorbent assay (ELISA). The free kappa results were compared with the IgG findings in 4 neurological patient groups with a distinct CSF IgG pattern: (1) CSF without ol...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2020
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000892